This ad will close in 15 seconds

From : nervousneuron
Added: Oct 9, 2009
Drug discrimination with rats can tell us a lot about the in vivo pharmacology of drugs, especially about their subjective effects. There is a pretty good correspondence between the discriminative effects of drugs and subjective effects in humans. Drug discrimination is an application of operant conditioning. Im using this for a research project tentatively called The Discriminative Stimulus Effects of Novel 5HT1a Agonists F15566 and F13714. I am not going to go into too much detail about that specifically; this video is more of an overview of how the drug discrimination experiment works. First, you guys gotta know what operant conditioning is to get whats going on. I also try to explain a bit about neurotransmission and what agonists and antagonists are and what they can do for us. I tried to keep it as simple as possible. But if you dont know basic psychology and pharmacology, it might be a whole lot of new information being blabbed at you at once. If youre into advanced behavioural pharmacology, you will laugh your arse off at this. If you guys dont like neuroscience, you will be bored to tears, unless you like listening to blah blah blah blah.., For those with a more advanced understanding: Ive kept the diagrams and explanation of the receptors simple. I know that an action potential in the next neuron doesnt happen just because the ligand bound to the receptor like its magic. Im not going to go into G-protein signaling, voltage gated channels and downstream cascades. Nor am I going to add detail which we dont need, like actin and docking proteins.... at least in this video ;) And they are diagrams and cartoons, not what the cells look like in real life lol! For example, cells dont change colour on receptor activation. Questions and comments appreciated :) ~*~*~Some cool videos about action potentials and synapses if you wanna know moar~*~*~ Sweet looking 3D action potential: http://www.youtube.com/watch?v=90cj4NX87Yk How an action potential is formed: http://www.youtube.com/watch?v=SCasruJT-DU How neurotransmitters are released into a synapse: http://www.youtube.com/watch?v=HXx9qlJetSU
Category : Tech

Video Categories:

Also Try: